If you are really concerned about weight, you can always try ordering PCBs made with a different material.
- Most PCBs (I think) are made with FR4 but you could get them made with Polyimide which is lighter.
- You could even make thinner PCBs. On Advanced Circuits you can order PCBs as thin as 0.02″ for a 2 or 4 layer board but that might be extreme.
- Since you are gonna have on-board connectors you can stick/glue the PCB on some other light but sturdy material (assuming all your components face up/are on the same side of your board).
- Now. the only weight you’ll really have in my opinion are the ICs.
Read More: Medical Electronics Manufacturing
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